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FLASH GENE
Symbol TSG101 contributors: mct/npt - updated : 23-09-2015
HGNC name tumor susceptibility gene 101
HGNC id 15971
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral somatic mutation      
mutated in primary breast carcinoma
tumoral     --over  
overexpressed in papillary thyroid carcinomas
tumoral somatic mutation      
in small cell lung carcinoma and in cervical, endometrial, hormone refractory prostate cancers
tumoral     --over  
in colorectal carcinoma (Ma 2008)
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • positive expression of PEG10 or TSG101 is a predictor of poor prognosis in gallbladder adenocarcinoma
    • Therapy target
    SystemTypeDisorderPubmed
    immunologyinfectious 
    is a potentially new attractive target for therapeutic intervention in AIDS
    ANIMAL & CELL MODELS