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FLASH GENE

Symbol

AHNAK2

contributors: mct - updated : 13-04-2016

HGNC name	AHNAK nucleoprotein 2
HGNC id	20125

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	41.10 kb     7 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_138420 7 - 18317 NP_612429 - 5795 - 2014 24675079

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum cardiac     Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Muscular myocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminal domain funtioning as a PDZ domain, PDZ domain structure containing a bound class III ligand peptide
	heptad repeat motifs similar to antiparallel beta-strands found in beta propeller proteins

HOMOLOGY

Homologene

FAMILY

giant propeller-like proteins family

CATEGORY

chaperone/stress

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic,vesicle
	intracellular,nucleus

basic FUNCTION	may be involved in regulating excitation/contraction coupling of cardiomyocytes
	is an important element of the FGF1 nonclassical export pathway

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

tight homodimerization may be central to the scaffolding functions of PRX and AHNAK2 in molecular complexes linking the extracellular matrix to the cytoskeletal network

INTERACTION

DNA

RNA

small molecule

protein	associated with L-type cacium channels
	in heat-shocked cells, FGF1 and the C-terminal fragment of AHNAK2 colocalized with F-actin in the vicinity of the cell membrane

cell & other

REGULATION

Other

phosphorylated by protein kinase

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS