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FLASH GENE
Symbol TDRD9 contributors: mct - updated : 25-03-2014
HGNC name tumor domain containing 9
HGNC id 20122
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
tumor domains
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nucleus
basic FUNCTION
  • ATP dependent helicase activity
  • TDRD1, TDRKH, TDRD9 and TDRD12, function in piRNA biogenesis and retrotransposon silencing
  • TDRD9 protects from replicative stress to TDRD9-positive tumor cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP binding
    protein
  • is a functional partner of PIWIL4
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPGF30
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in non-small cell lung carcinomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker marker for prognosis in a subset of lung carcinomas lung carcinomas
    Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    potential therapeutic target in a subset of lung carcinomas
    ANIMAL & CELL MODELS