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FLASH GENE

Symbol

TDRD9

contributors: mct - updated : 25-03-2014

HGNC name	tumor domain containing 9
HGNC id	20122

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_153046 36 - 4782 NP_694591 - 1382 - 2009 20059948

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

tumor domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION	ATP dependent helicase activity
	TDRD1, TDRKH, TDRD9 and TDRD12, function in piRNA biogenesis and retrotransposon silencing
	TDRD9 protects from replicative stress to TDRD9-positive tumor cells

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	nucleotide,
	ATP binding

protein

is a functional partner of PIWIL4

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

SPGF30

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in non-small cell lung carcinomas

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	marker for prognosis in a subset of lung carcinomas lung carcinomas
Therapy target
	System Type Disorder Pubmed cancer lung   potential therapeutic target in a subset of lung carcinomas

ANIMAL & CELL MODELS