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FLASH GENE
Symbol TDRD9 contributors: mct - updated : 25-03-2014
HGNC name tumor domain containing 9
HGNC id 20122
Corresponding disease
SPGF30 spermatogenic failure 30
Location 14q32.33      Physical location : 104.394.816 - 104.519.002
Synonym name
  • chromosome 14 open reading frame 75
  • hypoxia-inducible HIG-1
  • putative ATP-dependent RNA helicase TDRD9
    • Synonym symbol(s) DKFZp434N0820, FLJ36164, HIG-1, NET54, C14orf75, HLS, SPGF30, SPNE
    EC.number 3.6.4.13
    DNA
    TYPE functioning gene
    STRUCTURE 124.23 kb     36 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    36 - 4782 - 1382 - 2009 20059948
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		tumor domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • ATP dependent helicase activity
  • TDRD1, TDRKH, TDRD9 and TDRD12, function in piRNA biogenesis and retrotransposon silencing
  • TDRD9 protects from replicative stress to TDRD9-positive tumor cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP binding
    protein
  • is a functional partner of PIWIL4
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPGF30
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in non-small cell lung carcinomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker marker for prognosis in a subset of lung carcinomas lung carcinomas
    Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    potential therapeutic target in a subset of lung carcinomas
    ANIMAL & CELL MODELS