Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol DEGS2 contributors: mct - updated : 12-11-2012
HGNC name degenerative spermatocyte homolog 2, lipid desaturase (Drosophila)
HGNC id 20113
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a region important for C-4 hydroxylase activity, containing the sequence XAFGY (X=T or A or V; Y=T or N) and occuring on the C-terminal side of the first His-box
    • HOMOLOGY
    interspecies homolog to murine Des2
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • having oxidoreductase activity
  • playing an essential role in phytosphingolipid synthesis in skin and other phytosphingolipid-containing tissues
  • overexpression of DEGS1 or DEGS2 attenuated the dihydroceramide accumulation and increased cell proliferation during hypoxia
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by during during vitamin C/serum-induced differentiation of keratinocytes
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    of DEGS1 or DEGS2 attenuated the dihydroceramide accumulation and increased cell proliferation during hypoxia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS