Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ZDHHC22 contributors: mct - updated : 28-12-2021
HGNC name zinc finger, DHHC domain containing 22
HGNC id 20106
DNA
TYPE functioning gene
STRUCTURE 14.99 kb     3 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 3408 29 263 - 2018 29287726
3 - 3421 - 263 - 2018 29287726
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines glioblastomas
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • DHHC domain
    • HOMOLOGY
    interspecies homolog to rattus LOC299211
    Homologene
    FAMILY
  • DHHC palmitoyltransferase family
  • DHHC/NEW1 subfamily
    • CATEGORY enzyme , immunity/defense
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • palmitoyltransferase activity
  • might be involved in virus replication
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • palmitoylation by ZDHHC22, ZDHHC23 is essential for efficient cell surface expression of large conductance calcium-activated potassium (BK) channels
  • ZDHHC22, a palmityoltransferase, can interact with CCN3, and palmitoylation by ZDHHC22 at C241 in the CCN3 TSP1 domain may be required for the secretion of CCN3
  • viral protein NS1 triggers ZDHHC22 expression in transfected cells, whereas recombinant viruses lacking a functional NS1 gene did not cause ZDHHC22 upregulation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS