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FLASH GENE
Symbol ZDHHC22 contributors: mct - updated : 28-12-2021
HGNC name zinc finger, DHHC domain containing 22
HGNC id 20106
Location 14q24.3      Physical location : 77.597.613 - 77.608.134
Synonym name
  • chromosome 14 open reading frame 59
  • zinc finger, DHHC-type containing 22
    • Synonym symbol(s) c14orf59
    EC.number 2.3.1.225
    DNA
    TYPE functioning gene
    STRUCTURE 14.99 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 3408 29 263 - 2018 29287726
    3 - 3421 - 263 - 2018 29287726
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines glioblastomas
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • DHHC domain
    • HOMOLOGY
    interspecies homolog to rattus LOC299211
    Homologene
    FAMILY
  • DHHC palmitoyltransferase family
  • DHHC/NEW1 subfamily
    • CATEGORY enzyme , immunity/defense
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • palmitoyltransferase activity
  • might be involved in virus replication
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • palmitoylation by ZDHHC22, ZDHHC23 is essential for efficient cell surface expression of large conductance calcium-activated potassium (BK) channels
  • ZDHHC22, a palmityoltransferase, can interact with CCN3, and palmitoylation by ZDHHC22 at C241 in the CCN3 TSP1 domain may be required for the secretion of CCN3
  • viral protein NS1 triggers ZDHHC22 expression in transfected cells, whereas recombinant viruses lacking a functional NS1 gene did not cause ZDHHC22 upregulation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS