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FLASH GENE
Symbol CLEC14A contributors: mct - updated : 25-10-2017
HGNC name C-type lectin domain family 14, member A
HGNC id 19832
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one EGF-like domain
  • a C-type lectin-like domain (CTLD) that may be important for regulating cell migration and filopodia formation
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • thrombomodulin (TM) family
  • C-type lectin domain containing group 14 family
    • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text single-pass type I membrane protein
    basic FUNCTION
  • mediates cell–cell adhesion through its C-type lectin-like domain
  • may play a significant role in endothelial cell–cell adhesion
  • may potentially play an important role in vessel development
  • may play a critical role in the angiogenic function of endothelial cells (ECs) through interaction with other ECs or extracellular matrix proteins
  • induces filopodia and facilitates endothelial migration, tube formation and vascular development
  • is a regulator of sprouting angiogenesis
  • CLEC14A-MMRN2 binding has a role in inducing sprouting angiogenesis during tumour growth, which has the potential to be manipulated in future antiangiogenic therapy design
  • promotes sprouting angiogenesis and modulates endothelial function via interactions with extracellular matrix proteins
  • CLEC14A acts in vascular homeostasis by fine-tuning KDR and FLT4 signaling in ECs, suggesting its relevance in the pathogenesis of angiogenesis-related human disorders
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MMRN2 binds to the extracellular region of CLEC14A
  • the ectodomain of CLEC14A regulates sprouting angiogenesis, suggesting a role for RHBDL2 in endothelial function
  • HSPA1A and CLEC14A interact on endothelial cells, and this interaction regulates HSPA1A-induced angiogenesis
    • cell & other
    REGULATION
    Other is cleaved by rhomboid-like protein 2 (RHBDL2), one of 3 catalytic mammalian rhomboid-like (RHBDL) proteases, but that it is not cleaved by RHBDL1 or -3
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in tumor vasculature when compared with vessels in normal tissue
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may be a more specific endothelial marker to assess tumor angiogenesis
    • Therapy target
    SystemTypeDisorderPubmed
    cancerangiogenesis 
    blocking CLEC14A-MMRN2 binding inhibits sprouting angiogenesis and tumour growth
    ANIMAL & CELL MODELS
  • mice deficient in Clec14a display enhanced angiogenic sprouting and hemorrhage as well as enlarged jugular lymph sacs and lymphatic vessels