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FLASH GENE

Symbol

CLEC14A

contributors: mct - updated : 25-10-2017

HGNC name	C-type lectin domain family 14, member A
HGNC id	19832

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	2.37 kb     1 Exon(s)

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_175060 1 - 2256 NP_778230 - 490 - 2011 21095181

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel       moderately Homo sapiens Digestive mouth tongue     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone

cells

System Cell Pubmed Species Stage Rna symbol Cardiovascular endothelial cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	specifically expressed in the developing vasculature of endothelial cells

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one EGF-like domain
	a C-type lectin-like domain (CTLD) that may be important for regulating cell migration and filopodia formation

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY	thrombomodulin (TM) family
	C-type lectin domain containing group 14 family

CATEGORY

adhesion

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
text	single-pass type I membrane protein

basic FUNCTION	mediates cell–cell adhesion through its C-type lectin-like domain
	may play a significant role in endothelial cell–cell adhesion
	may potentially play an important role in vessel development
	may play a critical role in the angiogenic function of endothelial cells (ECs) through interaction with other ECs or extracellular matrix proteins
	induces filopodia and facilitates endothelial migration, tube formation and vascular development
	is a regulator of sprouting angiogenesis
	CLEC14A-MMRN2 binding has a role in inducing sprouting angiogenesis during tumour growth, which has the potential to be manipulated in future antiangiogenic therapy design
	promotes sprouting angiogenesis and modulates endothelial function via interactions with extracellular matrix proteins
	CLEC14A acts in vascular homeostasis by fine-tuning KDR and FLT4 signaling in ECs, suggesting its relevance in the pathogenesis of angiogenesis-related human disorders

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	MMRN2 binds to the extracellular region of CLEC14A
	the ectodomain of CLEC14A regulates sprouting angiogenesis, suggesting a role for RHBDL2 in endothelial function
	HSPA1A and CLEC14A interact on endothelial cells, and this interaction regulates HSPA1A-induced angiogenesis

cell & other

REGULATION

Other

is cleaved by rhomboid-like protein 2 (RHBDL2), one of 3 catalytic mammalian rhomboid-like (RHBDL) proteases, but that it is not cleaved by RHBDL1 or -3

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in tumor vasculature when compared with vessels in normal tissue

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	may be a more specific endothelial marker to assess tumor angiogenesis
Therapy target
	System Type Disorder Pubmed cancer angiogenesis   blocking CLEC14A-MMRN2 binding inhibits sprouting angiogenesis and tumour growth

ANIMAL & CELL MODELS

mice deficient in Clec14a display enhanced angiogenic sprouting and hemorrhage as well as enlarged jugular lymph sacs and lymphatic vessels