Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CLEC14A contributors: mct - updated : 25-10-2017
HGNC name C-type lectin domain family 14, member A
HGNC id 19832
Location 14q21.1      Physical location : 38.723.318 - 38.725.574
Synonym name
  • chromosome 14 open reading frame 27
  • ClECT and EGF-like domain containing protein
  • Epidermal growth factor receptor 5
    • Synonym symbol(s) CEG1, C14orf27, EGFR5, UNQ236/PRO269
    DNA
    TYPE functioning gene
    STRUCTURE 2.37 kb     1 Exon(s)
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 2256 - 490 - 2011 21095181
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel   moderately Homo sapiens
    Digestivemouthtongue  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text specifically expressed in the developing vasculature of endothelial cells
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one EGF-like domain
  • a C-type lectin-like domain (CTLD) that may be important for regulating cell migration and filopodia formation
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • thrombomodulin (TM) family
  • C-type lectin domain containing group 14 family
    • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text single-pass type I membrane protein
    basic FUNCTION
  • mediates cell–cell adhesion through its C-type lectin-like domain
  • may play a significant role in endothelial cell–cell adhesion
  • may potentially play an important role in vessel development
  • may play a critical role in the angiogenic function of endothelial cells (ECs) through interaction with other ECs or extracellular matrix proteins
  • induces filopodia and facilitates endothelial migration, tube formation and vascular development
  • is a regulator of sprouting angiogenesis
  • CLEC14A-MMRN2 binding has a role in inducing sprouting angiogenesis during tumour growth, which has the potential to be manipulated in future antiangiogenic therapy design
  • promotes sprouting angiogenesis and modulates endothelial function via interactions with extracellular matrix proteins
  • CLEC14A acts in vascular homeostasis by fine-tuning KDR and FLT4 signaling in ECs, suggesting its relevance in the pathogenesis of angiogenesis-related human disorders
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MMRN2 binds to the extracellular region of CLEC14A
  • the ectodomain of CLEC14A regulates sprouting angiogenesis, suggesting a role for RHBDL2 in endothelial function
  • HSPA1A and CLEC14A interact on endothelial cells, and this interaction regulates HSPA1A-induced angiogenesis
    • cell & other
    REGULATION
    Other is cleaved by rhomboid-like protein 2 (RHBDL2), one of 3 catalytic mammalian rhomboid-like (RHBDL) proteases, but that it is not cleaved by RHBDL1 or -3
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in tumor vasculature when compared with vessels in normal tissue
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may be a more specific endothelial marker to assess tumor angiogenesis
    • Therapy target
    SystemTypeDisorderPubmed
    cancerangiogenesis 
    blocking CLEC14A-MMRN2 binding inhibits sprouting angiogenesis and tumour growth
    ANIMAL & CELL MODELS
  • mice deficient in Clec14a display enhanced angiogenic sprouting and hemorrhage as well as enlarged jugular lymph sacs and lymphatic vessels