| basic FUNCTION
| involved in optic lobe formation, in specification of post limb mesoderm and in setting up the dorso/ventral limb axis |
|
controls the sinoatrial node gene program and imposes pacemaker function on the atria |
|
plays an important role on osteogenic differentiation and proliferation of human mesenchymal stem cell derived from adipose tissue  |
|
required for the molecular specification of the atrioventricular bundle and bundle branches and for the development of the ventricular septum and outflow tract |
|
having an indirect role in second heart field deployment |
|
potent inhibitor of senescence repressing CDKN2A |
|
directly repress the expression of E-cadherin, a keratinocyte-melanoma adhesion molecule whose loss is required for the acquisition of an invasive phenotype in melanoma |
|
as TBX2 may play a dual role during the radial to vertical growth phase transition by both inhibiting senescence via repression of CDKN1A expression, and enhancing melanoma invasiveness by decreasing E-cadherin level |
|
plays a crucial role in controlling hepatoblast proliferation and cell-fate determination by suppressing CDKN2A expression and thereby promoting liver organogenesis |
|
may function by recruiting HDACs to the T-box binding site in the promoter region |
|
regulates pluripotency-associated and reprogramming factors, in addition to sharing many common downstream regulatory targets with POU5F1, SOX2, NANOG and SMAD1 |
|
mediates limb, mammary gland and heart development ( |
|
|
|
functions as inhibiting senescence and thereby promoting cell proliferation and immortalization |
|
its function is important for the proliferation and specification of cells and tissues critical for development |
|
is required for the functional development, maturation, and homeostasis of the conduction system in a highly dosage-sensitive manner |
|
transcriptional repressor that is required for the development of the heart, limbs, and mammary glands |
|
plays distinct roles in regulating self-renewal and differentiation in hESCs |
|
plays a critical role in the developing heart in a dose-dependent manner |
|
may play an important role as a reciprocal switch between substrate dependent cell proliferation and tumour invasion |
|
TBX3 acts as an anti-apoptotic factor in mesangial cell (MC) and may be involved in the mechanism by which TGFB1 induces glomerulosclerosis and tubular fibrosis during the progression of nephropathies |
|
is involved in lineage specification in several tissues during embryonic development |
|
is important for the generation of hormone-sensing cells |
|
plays important roles in development, stem cells, nuclear reprogramming, and cancer |
|
is critical for the formation of, among other structures, the heart, limbs and mammary glands |
|
is likely required for cells to transit through S-phase and that this function may be linked to its role as a pro-proliferative factor |
|
TBX3 controls digit number upstream of SHH-dependent (posterior mesenchyme) and SHH-independent, cilium-based (anterior mesenchyme) Hedgehog pathway function |
|
is essential in development and has emerged as an important player in the oncogenic process |
|
is not only required for development of posterior forelimb bones (ulna and digits 4 and 5), but also for a subset of posterior muscles (lateral triceps and brachialis) and their bone eminence attachment sites |
|
represses BMP4 expression, and maintains eye field neural progenitors in a multipotent state, then, in combination with PAX6 determines eye field cells to form retina |
|
TBX2, TBX3, TBX4, TBX5 and three members of TBX1 (TBX1, TBX15, TBX18), Brachyury (T) and Eomes (TBR2) are expressed in the developing limb |
|
TBX18 and other members of the T-box gene family, namely, TBX1, TBX2, TBX3, and TBX20, play additional roles in development and homeostasis of other components of the excretory system |
