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FLASH GENE

Symbol

RND2

contributors: mct/npt - updated : 13-01-2015

HGNC name	Rho family GTPase 2
HGNC id	18315

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

LipoP , Other

HOMOLOGY

interspecies	homolog to murine Arhn
	homolog to C.elegans rhr-1

intraspecies

homolog to rho family (of GTP binding proteins)

Homologene

FAMILY	small GTPase superfamily
	Rho family
	Rnd subfamily

CATEGORY

regulatory , receptor membrane G

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,endosome

basic FUNCTION	GTPase, specifically involved in neuronal and hepatic functions
	involved in the regulation of endosomal trafficking via direct binding to VPS4A
	essential regulator of neuronal migration in the cerebral cortex and is a major effector of NEUROG2 function in the promotion of migration
	regulates neurite outgrowth by functioning as the RhoA activator through Pragmin, in contrast to RND1 and RND3 inhibiting RhoA signaling (Tanaka 2006)
	FNBP1 and RND2 cooperatively regulate spine density
	RND1, RND2, and RND3 are well known as key regulators of the actin cytoskeleton in various cell types, but they comprise a distinct subgroup of the RHO family in that they are GTP bound and constitutively active (pMID: 22357615)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule	nucleotide,
	GTP

protein	binding to the C terminus of SOC
	binding VPS4A
	interacting with NEUROG2
	RND2, binds to the HR1 domain of Rapostlin (FNBP1) (enhanced the Rapostlin-induced tubular membrane invagination)
	expression of RND2, a modulator of radial migration, is complementary to both these gradients and strongly increases in the absence of NR2F1 function
	RND1, RND2, RND3 bind directly to ARHGAP35 and equally induce activation of ARHGAP35
	RND1, RND2, and RND3 stability is acutely dependent on interaction with their effectors such as PLEKHG5 or ARHGAP35
	ZBTB18 represses NEUROG2 transcription to regulate the NEUROG2-RND2 pathway
	PLXNB1 binds in a GTP-dependent manner to RAC1, RAC2, RAC3, RND1, RND2, RND3, and RHOD
	KCTD13 and TNFAIP1 are interacting partners to RND proteins which influence the development of cortical neurons

cell & other

REGULATION

inhibited by

ZBTB18 (negative regulation of RND2 by ZBTB18 was important for cortical cell migration

repressed by

NR2F1 (directly represses RND2 expression at the post-mitotic level along the rostrocaudal axis of the neocortex) (PMId: 21965613)

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS