basic FUNCTION
| transcriptional repressor involved in organogenesis |
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having an important role in the interaactions of the pituitary-adrenal/gonadal axis during reproduction |
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enhancing the canonical Wnt signaling by localizing to heterochromatin |
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zinc-finger transcription factor linked to chromatin-mediated repression |
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modulates gene expression and regulates organogenesis, including kidney development |
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induces angiogenesis by stimulating VEGFA promoter activity |
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essential for ureteric bud attraction in kidney development |
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SALL1-dependent signals from the metanephric mesenchyme are required to modulate ureteric bud tip Wnt patterning in order to initiate branching |
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multi-zinc finger transcription factor that regulates kidney organogenesis |
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novel role for SALL1 as a member of the transcriptional network that regulates stem cell pluripotency |
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nuclear transcription factor, is required to maintain the stemness of nephron progenitor cells 2) |
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role for SALL1 in maintaining the stemness of the progenitor cell pool by restraining their differentiation into renal vesicles 2) |
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SALL1, is expressed in SIX2-positive progenitors as well as differentiating nascent nephrons, and it is essential for kidney formation |
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SALL1 marks cardiac progenitor cells (CPCs) in an undifferentiated state and regulates cardiac differentiation |
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regulates microglial morphology during development |
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transcriptional regulation by SALL1 maintains microglial identity and physiological properties in the CNS and allows microglia-specific manipulation |
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SALL1 is likely involved in feedback control, a common theme in SHH pathway regulation |