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FLASH GENE
Symbol S100A13 contributors: mct/npt - updated : 03-07-2009
HGNC name S100 calcium binding protein A13
HGNC id 10490
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two calcium binding domains with an Ef-hand-motif
  • two characteristic EF-hand domains
  • one S-100 specific Nter, one classical Cter
    • HOMOLOGY
    Homologene
    FAMILY
  • S-100 family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    text under stress, FGF1 and S100A13 colocalize at the plasma membrane (Graziani 2009)
    basic FUNCTION
  • involved in the regulation of FGF1 and SYT1 release in response to temperature stress
  • plays an important role in the secretion of FGF1 and interleukin 1alpha, two pro-angiogenic factors released by the endoplasmic reticulum/Golgi-independent non-classical secretory pathway (Imai 2006)
  • copper binding protein able to enhance the export of FGF1 in response to stress and to induce the formation of a multiprotein aggregate responsible for FGF1 release (Landriscina 2006)
  • calcium binding protein, known to participate in the non-classical secretion of signal peptide-less proteins, such as the acidic fibroblast growth factor (Kathir 2007)
  • participates also in the stress-dependent nonclassical export of IL1A and specifically associates with FGF1 at stress in glial cells (Graziani 2009)
  • small calcium-binding protein critical for FGF1 export (Graziani 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
    • protein
  • interacting with IL1A
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    of S100A13 and VEGFA expression correlated with the activation of angiogenesis in high-grade astrocytic gliomas (Landriscina 2006)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS