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FLASH GENE

Symbol

S100A13

contributors: mct/npt - updated : 03-07-2009

HGNC name	S100 calcium binding protein A13
HGNC id	10490

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1q21.3      Physical location : 153.591.279 - 153.606.568

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	15.30 kb     3 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 5 - 951 isoform 1 - 98 - Oh, Wicki (1996) variant 2 4 - 743 isoform 1 - 98 - Oh, Wicki (1996) variant 3 3 - 667 isoform 1 - 98 - Oh, Wicki (1996) variant 4 3 - 638 isoform 1 - 98 - Oh, Wicki (1996) variant 5 3 - 606 isoform 1 - 98 - Oh, Wicki (1996)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive intestine small intestine       Endocrine pancreas         Reproductive female system ovary       Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two calcium binding domains with an Ef-hand-motif
	two characteristic EF-hand domains
	one S-100 specific Nter, one classical Cter

HOMOLOGY

Homologene

FAMILY

S-100 family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	plasma membrane
text	under stress, FGF1 and S100A13 colocalize at the plasma membrane (Graziani 2009)

basic FUNCTION	involved in the regulation of FGF1 and SYT1 release in response to temperature stress
	plays an important role in the secretion of FGF1 and interleukin 1alpha, two pro-angiogenic factors released by the endoplasmic reticulum/Golgi-independent non-classical secretory pathway (Imai 2006)
	copper binding protein able to enhance the export of FGF1 in response to stress and to induce the formation of a multiprotein aggregate responsible for FGF1 release (Landriscina 2006)
	calcium binding protein, known to participate in the non-classical secretion of signal peptide-less proteins, such as the acidic fibroblast growth factor (Kathir 2007)
	participates also in the stress-dependent nonclassical export of IL1A and specifically associates with FGF1 at stress in glial cells (Graziani 2009)
	small calcium-binding protein critical for FGF1 export (Graziani 2009)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Ca2+

protein

interacting with IL1A

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   of S100A13 and VEGFA expression correlated with the activation of angiogenesis in high-grade astrocytic gliomas (Landriscina 2006)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS