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FLASH GENE
Symbol PLA2G16 contributors: mct - updated : 05-11-2008
HGNC name phospholipase A2, group XVI
HGNC id 17825
Location 11q12.3      Physical location : 63.341.943 - 63.381.941
Synonym name
  • similar to rat HREV107
  • H-RAS revertant cell lines homolog 107
  • HRAS-like suppressor 3
  • adipose-specific phospholipase A2
  • renal carcinoma antigen NY-REN-65
  • Ca-independent phospholipase A1/2
  • Synonym symbol(s) HREV107, HREV107-3, MGC118754, AdPLA, HRASLS3
    EC.number 3.1.1.4
    DNA
    TYPE functioning gene
    STRUCTURE 40.01 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1395 - 162 - 2008 18614531
    5 - 1111 - 162 - 2008 18614531
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
     liver    
    Hearing/Equilibriumear   highly
    Nervousbrain   highly
    Reproductivemale systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    not specificadipocyte
    Reproductivespermatid
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal proline-rich region which is the domain that is relevant for both binding of PPP2R1A and induction of programmed cell death
  • HOMOLOGY
    interspecies homolog to murine Hrasls3
    intraspecies homolog to H-RAS revertant cell lines107
    Homologene
    FAMILY
  • H-REV107 family
  • class II tumor suppressor gene family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • adipose-specific, calcium-dependent histidine PLA2
  • tumor suppressor that may be involved in interferon- dependent cell death
  • catalyzes the efficient release of free fatty acids (FFA) and lysophospholipid from phosphatidylcholine (PC), indicating that it is a phospholipase A (PLA)
  • has phospholipase activity but lacks acyltransferase activity
  • signaling regulatory molecule, which is functionally involved in the oncogenic network mediating growth and survival of ovarian cancer cells
  • with HRASLS2 and RARRES3, are involved in the phospholipid metabolism with different physiological roles
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PPP2R1A interaction partner of PLA2G16 (binds to the endogenous PPP2R1A, thereby partially sequestering the catalytic subunit PR36 from the PR65 protein complex, and inhibiting PP2A catalytic activity)
  • cell & other
    REGULATION
    induced by during preadipocyte differentiation into adipocytes
    inhibited by MAFP, an inhibitor of cysteine-dependent phospholipases
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    associated with invasive progression of testicular germ cell tumors
    tumoral     --low  
    in ovarian carcinomas
    Susceptibility to resistance to neoplastic transformation
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS