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FLASH GENE

Symbol

ZNF365

contributors: mct/npt - updated : 21-08-2015

HGNC name	zinc finger protein 365
HGNC id	18194

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function results in delayed mitotic progression and exit due to increased replication stress, ultimately leading to cytokinesis failure, re-duplication of centrosomes, and increased aneuploidy

Susceptibility

to uric acid nephrolithiasis to mammographic density and breast cancer to Crohn disease

Variant & Polymorphism other	mutation in ZNF365D associated to uric acid nephrolithiasis
	rs10995190 in ZNF365 associated with susceptibility to breast cancer
	variants in ZNF365 isoform D are associated with Crohn disease

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS