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FLASH GENE
Symbol ZNF365 contributors: mct/npt - updated : 21-08-2015
HGNC name zinc finger protein 365
HGNC id 18194
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal zinc finger domain, C2H2 type
  • a coiled coil-containing subdomain both sufficient and required for its centrosome localization
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    basic FUNCTION
  • centrosomal protein that can form a protein complex with NDE1 in the centrosome and plays an important role for successful mitosis
  • playing an essential role for cell division and abnormalities may cause aberrant chromosome segregation and may contribute to aneuploidy and malignant transformation
  • plays a critical role in stabilizing fragile sites within the genome and telomeres and maintaining genome stability
  • is necessary for timely resolution of replication intermediates of genomic fragile sites and, thus, for suppression of genomic instability
  • homologous recombination (HR) repair-dependent function of ZNF365 in preventing genomic instability
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with NDE1
  • direct TP53 target that promotes genome stability (TP53-ZNF365 axis contributes to genomic stability in the setting of telomere dysfunction)
  • interacts with poly(ADP-ribose) polymerase (PARP1) to tether MRE11 to the DNA end resection site
    • cell & other
    REGULATION
    induced by DNA double-strand break (DSB) signals, is involved in the homologous recombination (HR) repair pathway, and maintains genome integrity during DNA replication
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    results in delayed mitotic progression and exit due to increased replication stress, ultimately leading to cytokinesis failure, re-duplication of centrosomes, and increased aneuploidy
    Susceptibility
  • to uric acid nephrolithiasis
  • to mammographic density and breast cancer
  • to Crohn disease
    • Variant & Polymorphism other
  • mutation in ZNF365D associated to uric acid nephrolithiasis
  • rs10995190 in ZNF365 associated with susceptibility to breast cancer
  • variants in ZNF365 isoform D are associated with Crohn disease
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS