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FLASH GENE

Symbol

ZNF365

contributors: mct/npt - updated : 21-08-2015

HGNC name	zinc finger protein 365
HGNC id	18194

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014951 5 - 4223 NP_055766 - 407 - 2006 16547491 ZNF365 A NM_199450 5 - 1726 NP_955522 - 333 - 2006 16547491 ZNF365B NM_199451 8 - 3414 NP_955523 - 462 - 2006 16547491 ZNF365C NM_199452 - - 2695 NP_955524 24 216 - 2006 16547491 encoding the talanin, ZNF365D emerged during primate evolution from a noncoding genomic sequence that evolved in a standard gene structure associated with susceptibility to uric acid nephrolithiasis

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine parathyroid         Nervous brain

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal zinc finger domain, C2H2 type
	a coiled coil-containing subdomain both sufficient and required for its centrosome localization

HOMOLOGY

Homologene

FAMILY

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome

basic FUNCTION	centrosomal protein that can form a protein complex with NDE1 in the centrosome and plays an important role for successful mitosis
	playing an essential role for cell division and abnormalities may cause aberrant chromosome segregation and may contribute to aneuploidy and malignant transformation
	plays a critical role in stabilizing fragile sites within the genome and telomeres and maintaining genome stability
	is necessary for timely resolution of replication intermediates of genomic fragile sites and, thus, for suppression of genomic instability
	homologous recombination (HR) repair-dependent function of ZNF365 in preventing genomic instability

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting with NDE1
	direct TP53 target that promotes genome stability (TP53-ZNF365 axis contributes to genomic stability in the setting of telomere dysfunction)
	interacts with poly(ADP-ribose) polymerase (PARP1) to tether MRE11 to the DNA end resection site

cell & other

REGULATION

induced by

DNA double-strand break (DSB) signals, is involved in the homologous recombination (HR) repair pathway, and maintains genome integrity during DNA replication

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function results in delayed mitotic progression and exit due to increased replication stress, ultimately leading to cytokinesis failure, re-duplication of centrosomes, and increased aneuploidy

Susceptibility

to uric acid nephrolithiasis to mammographic density and breast cancer to Crohn disease

Variant & Polymorphism other	mutation in ZNF365D associated to uric acid nephrolithiasis
	rs10995190 in ZNF365 associated with susceptibility to breast cancer
	variants in ZNF365 isoform D are associated with Crohn disease

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS