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FLASH GENE
Symbol ZMYND11 contributors: npt/pgu - updated : 15-10-2015
HGNC name zinc finger, MYND domain containing 11
HGNC id 16966
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one MYND-type zinc finger, conserved zinc binding fold that plays important roles in transcriptional regulation by mediating distinct molecular interactions with viral and cellular proteins
  • tandemly arranged PHD, BROMO, and PWWP domains, which are chromatin recognition modalities
    • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Zmynd11 (97.00pc)
    homolog to rattus Zmynd11 (98.00pc)
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • may be acting as tumor suppressor through suppression of adenovirus replication
  • involved in the negative regulation of transcription, DNA-dependent
  • is involved in cellular senescence mainly through the TP53-CDKN1A pathway
  • controlling E1A stability via inhibition of ubiquitination
  • nuclear protein acting as a transcriptional repressor
  • positive regulator for the TLR3-TICAM1 pathway
  • harbors dual modes of cytoplasmic NF-kappaB regulation, positively in the TICAM1 pathway and negatively in the latent membrane protein 1 pathway
  • abrogates LTBR function through a protein-protein interaction
  • is an H3.3-specific reader of H3K36me3 that links the histone-variant-mediated transcription elongation control to tumour suppression
    • CELLULAR PROCESS cell cycle
    cell life, proliferation/growth
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    recruitment and aggregation of ZMYND11 is a prerequisite for JNK activation by LMP1
  • involved in the p53-p21Cip-mediated senescence pathway
    • a component
  • forming complex with both p53 and p400
    • INTERACTION
    DNA
  • associating with chromatin and mitotic chromosomes
  • associating with the p21Cip promoter through p53
    • RNA
    small molecule metal binding,
  • binding ions Zn2+
    • protein
  • binding to the transactivation domain of the adenovirus type 5 E1A 32kDa protein and inhibits its transactivating activity
  • interacts with PIAS1 (a well-characterized SUMO E3 enzyme) and UBE2I (the only SUMO E2 enzyme so far identified) through its distinct regions
  • directly interacted with TRAF3, a negative regulator of NF-kappaB activation
  • interacting with a set of chromatin remodeling factors, ATP-dependent helicases, histone deacetylases and histone methyltransferases as well as the E2F6 transcription factor
  • MAGEC2 is a new negative regulator of ZMYND11
  • selectively recognizes histone variant H3.3 lysine 36 trimethylation (H3.3K36me3) via its chromatin-binding domains, and connects histone H3.3 lysine 36 trimethylation-decorated chromatin to regulated pre-mRNA processing
    • cell & other
    REGULATION
    inhibited by phosphorylation upon DNA damage, probably by ATM or ATR
    repressed by the expression of adenovirus E1A protein
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL10PT , MRD30
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS