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FLASH GENE
Symbol ZMYND11 contributors: npt/pgu - updated : 15-10-2015
HGNC name zinc finger, MYND domain containing 11
HGNC id 16966
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one MYND-type zinc finger, conserved zinc binding fold that plays important roles in transcriptional regulation by mediating distinct molecular interactions with viral and cellular proteins
  • tandemly arranged PHD, BROMO, and PWWP domains, which are chromatin recognition modalities
    • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Zmynd11 (97.00pc)
    homolog to rattus Zmynd11 (98.00pc)
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • may be acting as tumor suppressor through suppression of adenovirus replication
  • involved in the negative regulation of transcription, DNA-dependent
  • is involved in cellular senescence mainly through the TP53-CDKN1A pathway
  • controlling E1A stability via inhibition of ubiquitination
  • nuclear protein acting as a transcriptional repressor
  • positive regulator for the TLR3-TICAM1 pathway
  • harbors dual modes of cytoplasmic NF-kappaB regulation, positively in the TICAM1 pathway and negatively in the latent membrane protein 1 pathway
  • abrogates LTBR function through a protein-protein interaction
  • is an H3.3-specific reader of H3K36me3 that links the histone-variant-mediated transcription elongation control to tumour suppression
    • CELLULAR PROCESS cell cycle
    cell life, proliferation/growth
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    recruitment and aggregation of ZMYND11 is a prerequisite for JNK activation by LMP1
  • involved in the p53-p21Cip-mediated senescence pathway
    • a component
  • forming complex with both p53 and p400
    • INTERACTION
    DNA
  • associating with chromatin and mitotic chromosomes
  • associating with the p21Cip promoter through p53
    • RNA
    small molecule metal binding,
  • binding ions Zn2+
    • protein
  • binding to the transactivation domain of the adenovirus type 5 E1A 32kDa protein and inhibits its transactivating activity
  • interacts with PIAS1 (a well-characterized SUMO E3 enzyme) and UBE2I (the only SUMO E2 enzyme so far identified) through its distinct regions
  • directly interacted with TRAF3, a negative regulator of NF-kappaB activation
  • interacting with a set of chromatin remodeling factors, ATP-dependent helicases, histone deacetylases and histone methyltransferases as well as the E2F6 transcription factor
  • MAGEC2 is a new negative regulator of ZMYND11
  • selectively recognizes histone variant H3.3 lysine 36 trimethylation (H3.3K36me3) via its chromatin-binding domains, and connects histone H3.3 lysine 36 trimethylation-decorated chromatin to regulated pre-mRNA processing
    • cell & other
    REGULATION
    inhibited by phosphorylation upon DNA damage, probably by ATM or ATR
    repressed by the expression of adenovirus E1A protein
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL10PT , MRD30
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS