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FLASH GENE

Symbol

ZMYND11

contributors: npt/pgu - updated : 15-10-2015

HGNC name	zinc finger, MYND domain containing 11
HGNC id	16966

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	120.17 kb     15 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006624 15 splicing 4411 NP_006615 66 562 - 2014 24590075 15 exons encoding the isoform A NM_212479 14 splicing 2345 NP_997644 61.7 567 - 2014 24590075 14 exons encoding isoform B NM_001202466 14 - 4268 NP_001189395 - 547 - 2014 24590075 NM_001202465 13 - 4168 NP_001189394 - 517 - 2014 24590075 NM_001202464 14 - 3968 NP_001189393 - 548 - 2014 24590075 NM_001202468 13 - 2407 NP_001189397 - 568 - 2014 24590075 NM_001202467 - - 2245 NP_001189396 - 514 - 2014 24590075

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth tongue

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one MYND-type zinc finger, conserved zinc binding fold that plays important roles in transcriptional regulation by mediating distinct molecular interactions with viral and cellular proteins
	tandemly arranged PHD, BROMO, and PWWP domains, which are chromatin recognition modalities

conjugated

PhosphoP

HOMOLOGY

interspecies	homolog to murine Zmynd11 (97.00pc)
	homolog to rattus Zmynd11 (98.00pc)

Homologene

FAMILY

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleoplasm
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	may be acting as tumor suppressor through suppression of adenovirus replication
	involved in the negative regulation of transcription, DNA-dependent
	is involved in cellular senescence mainly through the TP53-CDKN1A pathway
	controlling E1A stability via inhibition of ubiquitination
	nuclear protein acting as a transcriptional repressor
	positive regulator for the TLR3-TICAM1 pathway
	harbors dual modes of cytoplasmic NF-kappaB regulation, positively in the TICAM1 pathway and negatively in the latent membrane protein 1 pathway
	abrogates LTBR function through a protein-protein interaction
	is an H3.3-specific reader of H3K36me3 that links the histone-variant-mediated transcription elongation control to tumour suppression

CELLULAR PROCESS	cell cycle
	cell life, proliferation/growth
	nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

	recruitment and aggregation of ZMYND11 is a prerequisite for JNK activation by LMP1
	involved in the p53-p21Cip-mediated senescence pathway

a component

forming complex with both p53 and p400

INTERACTION

DNA	associating with chromatin and mitotic chromosomes
	associating with the p21Cip promoter through p53

RNA

small molecule	metal binding,
	binding ions Zn2+

protein	binding to the transactivation domain of the adenovirus type 5 E1A 32kDa protein and inhibits its transactivating activity
	interacts with PIAS1 (a well-characterized SUMO E3 enzyme) and UBE2I (the only SUMO E2 enzyme so far identified) through its distinct regions
	directly interacted with TRAF3, a negative regulator of NF-kappaB activation
	interacting with a set of chromatin remodeling factors, ATP-dependent helicases, histone deacetylases and histone methyltransferases as well as the E2F6 transcription factor
	MAGEC2 is a new negative regulator of ZMYND11
	selectively recognizes histone variant H3.3 lysine 36 trimethylation (H3.3K36me3) via its chromatin-binding domains, and connects histone H3.3 lysine 36 trimethylation-decorated chromatin to regulated pre-mRNA processing

cell & other

REGULATION

inhibited by

phosphorylation upon DNA damage, probably by ATM or ATR

repressed by

the expression of adenovirus E1A protein

ASSOCIATED DISORDERS

corresponding disease(s)

DEL10PT , MRD30

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS