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FLASH GENE

Symbol

ARAP3

contributors: mct - updated : 23-05-2018

HGNC name	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
HGNC id	24097

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune thymus

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Epithelial         Epithelial barrier/lining retinal pigment epithelium (RPE)

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a Ras association (RA) domain that interacts with the small G-protein Rap1
	a sterile alpha motif (SAM) domain

HOMOLOGY

Homologene

FAMILY

CATEGORY

DNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,cytoplasm,cytoskeleton

basic FUNCTION	having DNA binding activity
	regulates chemotaxis and adhesion-dependent processes in neutrophils
	a GTPase activating protein for RHO and ARF family GTPases, that is one of many phosphoinositide 3-OH kinase (PI3K) effectors
	regulates lymphatic vascular development
	despite a critical role for ARAP3 in embryonic vascular development, its loss in endothelial cells minimally impacts HSCs in adult bone marrow
	is unique for its dual specificity GAPs (GTPase-activating protein) activity for ARF6 and RHOA regulated by phosphatidylinositol 3,4,5-trisphosphate and a small GTPase RAP1-GTP and is involved in regulation of cell shape and adhesion

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signaling pathway that controls angiogenesis immediately downstream of PIK3CA through ARAP3 to the RHO and ARF family of small GTPases

a component

INTERACTION

DNA

RNA

small molecule

protein	DISC1
	CENTD3 is an interaction partner for VAV2
	is a GTPase-activating protein (GAP) that inactivates ARF6 and RHOA small GTPases

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	Arap3 deficiency in mice causes a sprouting angiogenic defect resulting in embryonic lethality by E11
	Arap3 is dysregulated in a mouse model of hypotrichosis-lymphedema-telangiectasia