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FLASH GENE
Symbol ACAD9 contributors: mct - updated : 11-06-2013
HGNC name acyl-Coenzyme A dehydrogenase family, member 9
HGNC id 21497
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • mitochondrial acyl-CoA dehydrogenase protein family
  • CATEGORY enzyme , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    basic FUNCTION
  • involved in electron transport
  • long-chain acyl-CoA dehydrogenase in embryonic and fetal central nervous tissue, that may play a role in the turnover of lipid membrane unsaturated fatty acids essential for membrane integrity and structure
  • playing a role in the mitochondrial beta-oxidation of long-chain unsaturated fatty acids
  • playing a possible role in the recycling of complex neural lipids and production of intermediate metabolites for synthetic pathways
  • role for ACAD9 in oxidative phosphorylation
  • new function in complex I function, making this gene an important new candidate for patients with complex I deficiency, which could be improved by riboflavin treatment
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism
    signaling
    a component
  • TMEM126B forms a complex with other assembly factors: NDUFAF1, ACAD9, and ECSIT
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds complex I assembly factors NDUFAF1 and ECSIT and is specifically required for the assembly of complex I
  • TIMMDC1 reciprocally associate with multiple components of the ECSIT-TMEM126B-ACAD9-NDUFAF1 assembly factor complex (MCIA complex), as well as subunits of the soluble and matrix arms
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ACAD9D
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS