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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

SLC5A8

contributors: mct/npt/pgu - updated : 30-06-2014

HGNC name	solute carrier family 5 (iodide transporter), member 8
HGNC id	19119

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral         silenced by methylation in colon cancer, and in papillary thyroid carcinomas of classical form (associated with T1796A point mutation of the BRAF) gene tumoral     --over   in colorectal cancer correlates with longer disease-free survival tumoral     --low   by aberrant promoter methylation in pancreatic adenocarcinoma tumoral     --low   DNA methylation in the SLC5A8 promoter region may suppress the expression of SLC5A8 in lung tumor (

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     novel regulatory sequence that may be used to increase expression of the SLC5A8 gene in cancer gene therapy cancer reproductive breast pharmacological approaches to reactivate SLC5A8 expression in tumor cells have potential as a novel therapeutic strategy for breast cancer treatment

ANIMAL & CELL MODELS