| basic FUNCTION
| thyroid apical iodide transporter, mediating iodide uptake in the thyroid gland |
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sodium solute symporter, that may be a favorable indicator of colorectal cancer prognosis |
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play a differential role in monocarboxylate transport in the retina in a cell type-specific manner |
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involved in lactate absorption in the latter parts of the renal proximal tubule |
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transports not only nicotinate and its structural analogs but also various monocarboxylate drugs |
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may participate in the intestinal absorption of monocarboxylate drugs |
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high-affinity transporter involved in lactate absorption in the latter parts of the proximal tubule  |
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physiologic functions of SLC5A8 include absorption of short-chain fatty acids in the colon and small intestine, reabsorption of lactate and pyruvate in the kidney, and cellular uptake of lactate and ketone bodies in neurons |
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can also transport a variety of pharmacologically relevant monocarboxylates, including salicylates, benzoate, and gamma-hydroxybutyrate |
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function as a tumor suppressor gene whose silencing by epigenetic changes may contribute to carcinogenesis and progression of pancreatic cancer |
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possesses a anionic leak current that becomes significant whenever external Na(+) concentration is reduced |
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induces Na(+)-dependent transport of pyroglutamate that is inhibitable by various SLC5A8 substrates |
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SLC5A8 nuclear translocation and loss of expression are associated with poor outcome in pancreatic ductal adenocarcinoma |
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sodium-coupled transporter for monocarboxylates |
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suppresses tumour progression through depletion of survivin without involving its transport function |
