protein
| mediating interaction between BLOC1S3 and and the switch I and II regions of RAB9A (Kloer 2010) |
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specific and strong interaction of HPS1, HPS4 with the GTP-bound form of the endosomal GTPase, RAB9A, RAB9B ![](pubmed.jpg) |
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HPS1 and HPS4 encode the HPS1 and HPS4 proteins, which assemble to form a complex known as Biogenesis of Lysosome-related Organelle Complex 3 (BLOC1S3) ![](pubmed.jpg) |
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VAMP7 mediates fusion of BLOC1S6-dependent transport carriers with melanosomes, and illuminate SNARE recycling from melanosomes as a critical HPS4-dependent step ![](pubmed.jpg) |
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HPS4 is required for activation of RAB32/RAB38 GTPases in melanogenesis, but its RAB9 activity is dispensable for melanogenesis ![](pubmed.jpg) |