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FLASH GENE
Symbol EGFL7 contributors: mct/pgu - updated : 09-11-2013
HGNC name EGF-like-domain, multiple 7
HGNC id 20594
Location 9q34.3      Physical location : 139.557.376 - 139.567.129
Synonym name
  • vascular endothelial statin
  • multiple EGF-like domain protein 7
  • multiple epidermal growth factor-like domain protein
  • NOTCH4-like protein
  • Synonym symbol(s) ZNEU1, VE-STATIN, MGC111117, RP11-251M1
    DNA
    TYPE functioning gene
    STRUCTURE 9.70 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC389809 9 LOC389809 LHX3 9q34.3 LIM homeobox protein 3 QSCN6L1 9q34.3 quiescin Q6-like 1 AGS3 9q34.3 activator of G-protein signaling 3 LOC389810 9 LOC389810 CARD9 9q34.3 caspase recruitment domain family, member 9 SNAPC4 9q34.2-q34.3 small nuclear RNA activating complex, polypeptide 4, 190kDa SDCCAG3 9q34.3 serologically defined colon cancer antigen 3 PMPCA 9q34.3 peptidase (mitochondrial processing) alpha INPP5E 9q34.3 inositol polyphosphate-5-phosphatase, 72kDa KIAA0310 9q34.1 inositol polyphosphate-5-phosphatase, 72kDa FLJ36779 9q34.3 hypothetical protein FLJ36779 NOTCH1 9q34.3 Notch homolog 1, translocation-associated (Drosophila) LOC389811 9 similar to HSPC324 EGFL7 9q34.3 EGF-like-domain, multiple 7 AGPAT2 9q34.3 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta) MGC20262 9q34.3 hypothetical protein MGC20262 MGC16037 9q34.3 hypothetical protein MGC16037 LCN6 9q34.3 lipocalin 6 LOC138307 LOC389812 LOC392401 9 similar to vacuolar H(+)-ATPase subunit; V-ATPase subunit; M16 MGC14141 9q34.3 hypothetical protein MGC14141 MGC15438 9q34.3 hypothetical protein MGC15438 FLJ10101 9q34.3 FLJ10101 protein LOC389813 9 similar to ENSANGP00000006371 PHP14 9q34.3 phosphohistidine phosphatase AEGP 9q34.3 apical early endosomal glycoprotein precursor EDF1 9q34.3 endothelial differentiation-related factor 1 TRAF2 9q34 TNF receptor-associated factor 2 FBXW5 9q34.3 F-box and WD-40 domain protein 5 C8G 9q22.33-q32 complement component 8, gamma polypeptide MGC48935 9q34.3 hypothetical protein MGC48935 LOC203235 9q34.3 hypothetical LOC203235 PTGDS 9q34.2-q34.3 prostaglandin D2 synthase 21kDa (brain) LOC286257 9q34.3 hypothetical protein LOC286257 CLIC3 9q34.3 chloride intracellular channel 3 ABCA2 9q34.3 ATP-binding cassette, sub-family A (ABC1), member 2 FUT7 9q34.3 fucosyltransferase 7 (alpha (1,3) fucosyltransferase) LOC389814 9 similar to LPAL6438 NPDC1 9q34.3 neural proliferation, differentiation and control, 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 1569 - 273 - -
    10 - 1571 - 273 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel   specific Homo sapiens
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarykidney    
    Visualeyeuveachoroid  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/liningretinal pigment epithelium (RPE)  
    Nervouscentral   
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell Homo sapiens
    cell lineage endothelial progenitor cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal sequence
  • an EMI domain domain at the N-terminus (domain present in a number of extracellular-matrix-associated proteins involved in regulating cell-adhesion)
  • two EGF-like domains and a leucine and valine-rich C-terminal region
  • HOMOLOGY
    interspecies homolog to murine Egfl7 (78.7pc)
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • playing a specific role in regulating vascular tubulogenesis
  • secreted factor implicated in cellular responses such as cell migration and blood vessel formation
  • acting as an antagonist of Notch signalling and affecting neural stem cell renewal
  • may protect endothelial cell from hyperoxia-induced apoptosis by inhibition of mitochondria-dependent apoptosis pathway
  • chemoattractant for endothelial cells, and its expression is restricted to endothelial cells
  • potentially regulates angiogenesis by an autocrine mechanism involving vasculature alone
  • its expression in tumors promotes tumor progression by reducing the expression of endothelial molecules that mediate immune cell infiltration
  • its function in blood vessel development is mediated, at least in part, through modulation of NOTCH signaling
  • role for EGFL7 in developmental and postnatal angiogenesis
  • extracellular matrix-associated protein expressed in activated endothelium
  • CELLULAR PROCESS cell migration & motility
    PHYSIOLOGICAL PROCESS development
    text blood vessel development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • binding transmembrane receptors of the Notch Family
  • CASZ1 is required to directly regulate an EGFL7/RhoA-mediated pathway to promote vertebrate vascular development
  • transcriptional pathway involving activation of EGFL7 gene by the transcription factor CASTOR (CASZ1) is required for blood vessel assembly and lumen morphogenesis
  • cell & other
    REGULATION
    activated by hypoxia that upregulates human coronary artery endothelial cells expression of EGFL7 and EGFL7 inhibits expression of intercellular adhesion molecule 1 subsequent to Hypoxia/reoxygenation (H/R) injury
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    significantly upregulated in human epithelial tumor tissues
    tumoral     --over  
    expression is significantly higher in invasive ductal than in invasive lobular breast carcinoma
    constitutional     --low  
    with ACVRL1 showed lower expression in early-onset pre-eclampsia versus late-onset pre-eclampsia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • potential biomarker for human epithelial tumors, especially hepatocellular carcinoma and breast cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    anti-EGFL7 antibodies enhance stress-induced endothelial cell death and anti-VEGF efficacy
    ANIMAL & CELL MODELS