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FLASH GENE

Symbol

DYNLRB2

contributors: - updated : 21-02-2006

HGNC name	dynein, light chain, roadblock-type 2
HGNC id	15467

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

constitutive of

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive intestine large intestine colon   moderately   intestine small intestine     highly   liver       lowly Endocrine pancreas       moderately Lymphoid/Immune spleen       moderately   thymus       lowly Nervous brain       highly Reproductive male system testis     moderately   male system prostate     highly Respiratory lung       lowly Urinary kidney       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text	placenta (highly)

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	ortholog to murine Dncl2b
	homolog to rattus Rn.27744
	homolog to Xenopus Xl.6973

Homologene

FAMILY

GAMAD family

CATEGORY

motor/contractile

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule

basic FUNCTION	involved in microtubule-based movement
	involved in assembly and motor function of dynein

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

dynein light chain

INTERACTION

DNA

RNA

small molecule

protein

binding with BMF and BCL2L11

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in hepatocellular carcinoma

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS