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FLASH GENE
Symbol DYNLRB2 contributors: - updated : 21-02-2006
HGNC name dynein, light chain, roadblock-type 2
HGNC id 15467
Location 16q23.3      Physical location : 80.574.853 - 80.584.539
Synonym name
  • dynein, cytoplasmic, light polypeptide 2B
  • roadblock/LC7-like
  • dynein light chain 2B
  • bithoraxoid-like protein
    • Synonym symbol(s) DNLC2B, MGC62033, DNCL2B
    DNA
    TYPE functioning gene
    STRUCTURE 9.00 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveintestinelarge intestinecolon moderately
     intestinesmall intestine  highly
     liver   lowly
    Endocrinepancreas   moderately
    Lymphoid/Immunespleen   moderately
     thymus   lowly
    Nervousbrain   highly
    Reproductivemale systemtestis  moderately
     male systemprostate  highly
    Respiratorylung   lowly
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta (highly)
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to murine Dncl2b
    homolog to rattus Rn.27744
    homolog to Xenopus Xl.6973
    Homologene
    FAMILY GAMAD family
    CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • involved in microtubule-based movement
  • involved in assembly and motor function of dynein
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component dynein light chain
    INTERACTION
    DNA
    RNA
    small molecule
    protein binding with BMF and BCL2L11
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in hepatocellular carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS