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FLASH GENE

Symbol

PTPRS

contributors: mct - updated : 21-04-2022

HGNC name	protein tyrosine phosphatase, receptor type, S
HGNC id	9681

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in Hepatocellular carcinoma (HCC)

Susceptibility

to type 2 diabetes (T2D)

Variant & Polymorphism SNP	association of SNPs in PTPRS gene with T2D

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed neurology acquired   potential new target for enhancing axonal growth and plasticity after nervous system injury

ANIMAL & CELL MODELS

half of the mouse embryos lacking both Ptprs and Ptprf (LAR) exhibit micrognathia (small lower jaw), cleft palate and microglossia/glossoptosis (small and deep tongue), a phenotype closely resembling Pierre-Robin