Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PTPRS contributors: mct - updated : 21-04-2022
HGNC name protein tyrosine phosphatase, receptor type, S
HGNC id 9681
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 8 fibronectin type-III domains
  • three Ig-like C2-type (immunoglobulin-like) domains
  • two tyrosine-protein phosphatase domains
    • HOMOLOGY
    Homologene
    FAMILY
  • protein-tyrosine phosphatase family, receptor class 2A subfamily
  • Leukocyte antigen related (LAR) family receptor
  • LAR-RPTP subfamily
    • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • tyrosine phosphatase receptor, putatively involved in the development of the nervous system
  • may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis
  • PTPRD, PTPRS regulate neuroendocrine development, axonal regeneration, and hippocampal long-term potentiation
  • PTPRD and PTPRS complement each other functionally during mammalian development, and have an essential contribution to appropriate motoneuron axon targeting during axonogenesis
  • important role in the development of the nervous system and nerve regeneration
  • modulates the actin cytoskeleton by regulating Rac GTPase activity through ARHGAP32
  • modulates Rac dependent activity through regulating a novel substrate, ARHGAP32
  • acts bimodally in sensory neuron extension, mediating chondroitin sulfate proteoglycans (CSPG)inhibition and heparan sulfate proteoglycans growth (HSPG) promotion
  • PTPRS clustering would translate into an uneven distribution of phosphatase activity on the cell surface, consistent with localization-based models for receptor action
  • PTPRS represents an evolutionarily conserved Plasmacytoid dendritic cells (pDCs)-specific inhibitory receptor, and is required to prevent spontaneous IFN production and immune-mediated intestinal inflammation
  • PTPRS, PTPRD, PTPRF participate in several brain functions
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with PPFIA1, PPFIA2 and PPFIA3
  • receptor for inhibitory chondroitin sulfate proteoglycan
  • interaction with PPFIA4, BCAR1, TRIO
  • ARHGAP32 is a novel substrate of PTPRS and PTPRS displayed its phosphatase specificity toward ARHGAP32
  • SLITRK1, SLITRK2, SLITK3, SLITRK4, SLITRK5 and SLITRK6 appeared to interact with both PTPRD and PTPRS
  • NME2 interacts with PTPRS, and NME2 associates with PTPRS to elicit neurite outgrowth inhibition in response to chondroitin sulfate proteoglycans (CSPGs)
  • PTPRS regulate RAS pathway activation through ERK, and modulates ERK phosphorylation and subsequent translocation to the nucleus
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in Hepatocellular carcinoma (HCC)
    Susceptibility
  • to type 2 diabetes (T2D)
    • Variant & Polymorphism SNP
  • association of SNPs in PTPRS gene with T2D
    • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurologyacquired 
    potential new target for enhancing axonal growth and plasticity after nervous system injury
    ANIMAL & CELL MODELS
  • half of the mouse embryos lacking both Ptprs and Ptprf (LAR) exhibit micrognathia (small lower jaw), cleft palate and microglossia/glossoptosis (small and deep tongue), a phenotype closely resembling Pierre-Robin