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FLASH GENE
Symbol ICA1L contributors: mct - updated : 07-05-2020
HGNC name islet cell autoantigen 1,69kDa-like
HGNC id 14442
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
an arfaptin domain
HOMOLOGY
interspecies ortholog to murine Ica1l
Homologene
FAMILY
CATEGORY signaling
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,Golgi
intracellular,cytoplasm,cytosolic,vesicle
text by inference
basic FUNCTION
  • putative signal transducer
  • is crucial for acrosome formation in spermiogenesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ARF1
  • ICA1L is expressed in testes and brain, and is the major binding partner for PICK1 in testes
  • it is likely that SRF-ICA1L fusions define a similar subset of neoplasms composed of immature smooth muscle cells
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    SRF-ICA1L gene fusion, in cellular myoid tumors
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • sperm from Ica1l-knockout mice had abnormalities in the acrosome, nucleus and mitochondrial sheath formation