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FLASH GENE
Symbol ICA1L contributors: mct - updated : 07-05-2020
HGNC name islet cell autoantigen 1,69kDa-like
HGNC id 14442
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas   highly
Nervousbrain   highly Homo sapiens
Reproductivemale systemtestis  highly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivespermatid Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
an arfaptin domain
HOMOLOGY
interspecies ortholog to murine Ica1l
Homologene
FAMILY
CATEGORY signaling
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,Golgi
intracellular,cytoplasm,cytosolic,vesicle
text by inference
basic FUNCTION
  • putative signal transducer
  • is crucial for acrosome formation in spermiogenesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ARF1
  • ICA1L is expressed in testes and brain, and is the major binding partner for PICK1 in testes
  • it is likely that SRF-ICA1L fusions define a similar subset of neoplasms composed of immature smooth muscle cells
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    SRF-ICA1L gene fusion, in cellular myoid tumors
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • sperm from Ica1l-knockout mice had abnormalities in the acrosome, nucleus and mitochondrial sheath formation