SUBCELLULAR LOCALIZATION
| extracellular
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| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,organelle,endosome
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| intracellular,cytoplasm,organelle,lysosome
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| intracellular,cytoplasm,cytosolic,granule
|
text
| lysosome-like vacuoles |
basic FUNCTION
| playing a key role in cholesterol homeostasis through processing the sterol regulatory element-binding proteins |
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implicated in the differentiation of cortical neurons |
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plays a major role in determining plasma levels of LDL-C |
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acting as a natural inhibitor of the low density lipoprotein receptor pathway, and both genes are regulated by depletion of cholesterol cell content and statins, via sterol regulatory element-binding protein (SREBP) |
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having a general effect on the degradation of the LDLR family that emphasizes its major role in cholesterol and lipid homeostasis as well as brain development |
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enhancing the degradation of LDLR and its closest family members LRP8 and VLDLR, but not LRP1 |
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play a major role in cholesterol homeostasis through enhanced degradation of the low-density lipoprotein receptor (LDLR) and possibly in neural development |
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plays an important role in regulating LDL receptor degradation |
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post-translationally regulates the number of cell-surface low density lipoprotein receptors (LDLR) |
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enhances the degradation of the LDLR in endosomes/lysosomes, upregulating LDL-cholesterol levels |
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degrade the low-density lipoprotein (LDL) receptor independently of its catalytic activity |
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binds to the epidermal growth factor domain A (EGFA) of low-density lipoprotein receptor (LDLR) and leads to its destruction |
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its function could reflect ancient roles in the fasting-feeding cycle and in linking lipoprotein metabolism with innate immunity |
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secreted protein that promotes degradation of cell surface LDL receptors (LDLRs) in selected cell types |
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PCSK9 might increase oxidized LDL uptake and impair macrophage-mediated reverse cholesterol transport, contributing to the development of atherosclerosis |
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plays a key role in regulating cholesterol homeostasis |
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may regulate apoptosis through mitochondrial pathway |
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OLR1 and PCSK9 positively influence each other's expression, especially during an inflammatory reaction |
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is a gene involved in lipid metabolism regulated by proinflammatory cytokine TNF in a SOCS3-dependent manner |
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play a role in impaired fetal growth by controlling fetal LDL-C metabolism, which seems to be dependent on gestational age and fetal gender |