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FLASH GENE
Symbol ARHGAP18 contributors: mct - updated : 06-12-2023
HGNC name Rho GTPase activating protein 18
HGNC id 21035
Location 6q22.33      Physical location : 129.898.240 - 130.031.370
Synonym name MacGAP protein
Synonym symbol(s) MacGAP, bA307O14.2, FLJ25728, MGC126757, MGC138145, SENEX,
DNA
TYPE functioning gene
STRUCTURE 133.13 kb     15 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 3503 - 663 - 2020 32013974
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinethyroid    
Lymphoid/Immunethymus    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a pleckstrin homology (PH) domain
  • a RhoGAP domain
  • HOMOLOGY
    interspecies ortholog to drosophila Conu
    homolog to murine Arhgap18 (85.3pc)
    homolog to rattus Arhgap18 (85.8pc)
    Homologene
    FAMILY RhoGAP gene family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text
  • localized to the leading edge during cell spreading and migration
  • a proportion of ARHGAP18 localizes to microtubules in endothelial cells, as well as in nonendothelial cells
  • basic FUNCTION
  • Rho GTPase-activating protein that modulates cell signaling
  • GTPase activator for the Rho-type GTPases, by converting them to an inactive GDP-bound state
  • required for the polarization of cells for migration and is one of the crucial factors for the regulation of RHOA for the control of cell shape, spreading, and migration
  • regulates likely RHOA and proliferation through interactions with MSN
  • ARHGAP18 as a specific RhoGAP to fine tune vascular morphogenesis, limiting tip cell formation and promoting junctional integrity to stabilize the angiogenic architecture
  • ARHGAP18 in endothelial cells is important in cell junctions
  • in endothelial cells, ARHGAP18 may act as a significant regulator of vascular homeostasis
  • ARHGAP18 controls angiogenesis, cellular morphology and motility
  • plays a potential role in regulating HbF expression in beta-thalassaemia
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
  • GTP binding
  • protein
  • interacting with MPHOSPH6
  • YAP1 is downstream of ARHGAP18 in mature endothelial cells and this pathway is involved in the athero-protective alignment of endothelial cells under laminar shear stress
  • negative feedback regulatory mechanism of Rho signaling mediated by PKN3-induced ARHGAP18 activation
  • GATA1 could bind to the ARHGAP18 promoter and facilitate ARHGAP18 expression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    suppressed the activity of RHOoA and disrupted stress fiber formation
    tumoral     --over  
    in hepatocellular carcinoma (HCC) tissues compared to adjacent nontumor tissues, and its overexpression is associated with poor survival
    Susceptibility to schizophrenia
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    GATA1-mediated ARHGAP18 might be a potential therapeutic target for HCC
    bloodhemoglobin 
    may be a promising therapeutic target in beta-thalassemia
    ANIMAL & CELL MODELS