basic FUNCTION
| Rho GTPase-activating protein that modulates cell signaling |
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GTPase activator for the Rho-type GTPases, by converting them to an inactive GDP-bound state |
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required for the polarization of cells for migration and is one of the crucial factors for the regulation of RHOA for the control of cell shape, spreading, and migration |
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regulates likely RHOA and proliferation through interactions with MSN |
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ARHGAP18 as a specific RhoGAP to fine tune vascular morphogenesis, limiting tip cell formation and promoting junctional integrity to stabilize the angiogenic architecture |
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ARHGAP18 in endothelial cells is important in cell junctions |
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in endothelial cells, ARHGAP18 may act as a significant regulator of vascular homeostasis |
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ARHGAP18 controls angiogenesis, cellular morphology and motility |
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plays a potential role in regulating HbF expression in beta-thalassaemia |