SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,organelle,endosome
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| intracellular,cytoplasm,organelle,lysosome
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| intracellular,cytoplasm,cytosolic
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| intracellular,nucleus,nucleoplasm
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| text
| LITAF mutants A111G, G112S, W116G, and T115N mislocalize from the late endosome/lysosome to the mitochondria while the mutants T49M, L122V, and P135T show partial mislocalization with a portion of the total protein present in the late endosome/lysosome and the remainder of the protein localized to the mitochondria  |
| basic FUNCTION
| playing an important role in the regulation of tumor necrosis factor alpha (TNFA) |
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may be clathrin adaptor aiding in the retention of ubiquitinated proteins on to the endosomes |
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E3 ubiquitin ligase playing a role in protein degradation |
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multiple functional molecule whose sequence is identical to the small integral membrane protein of the lysosome/late endosome |
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mediates the effect of AMPK by binding to a specific sequence in the promoter region |
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may function as a tumor suppressor |
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is a post-translationally inserted, C-tail-anchored membrane protein |
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transcription factor that mediates TNF1 expression ( |
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LITAF function is not absolutely required for peripheral nerve development and maintenance |
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function of LITAF as a regulator of endosomal trafficking, providing evidence linking dysregulated endosomal trafficking to CMT pathogenesis |
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LITAF traffics through the secretory pathway to the late endosome/lysosome |
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is a novel player in multivesicular bodies (MVBs) regulation |
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is an endosome-associated integral membrane protein important for multivesicular body sorting |
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is a monotopic membrane protein whose membrane integration is stabilised by a zinc finger |
