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FLASH GENE
Symbol LITAF contributors: mct - updated : 30-11-2012
HGNC name lipopolysaccharide-induced TNF factor
HGNC id 16841
Corresponding disease
CMT1C Charcot-Marie-Tooth disease, demyelinating, type 1C
Location 16p13.13      Physical location : 11.641.581 - 11.681.322
Synonym name
  • small integral membrane protein of lysosome/late endosome
  • tumor protein p53 inducible protein 7
  • Synonym symbol(s) PIG7, CMT1C, SIMPLE, TP53I7, FLJ38636, MGC116698, MGC116700, MGC116701
    DNA
    TYPE functioning gene
    STRUCTURE 39.74 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    ATF7IP2 16p13.2 activating transcription factor 7 interacting protein 2 EMP2 16p13.2 epithelial membrane protein 2 FLJ32871 16p13.2 hypothetical protein FLJ32871 NUBP1 16p13.1 nucleotide binding protein 1 (MinD homolog, E. coli) LOC283816 16p13.2 similar to ARHGAP21 protein MHC2TA 16p13 MHC class II transactivator DEXI 16p13.2 dexamethasone-induced transcript KIAA0350 16p13.13-p13.3 dexamethasone-induced transcript LOC390674 16 similar to Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1 / hnRNP C2) SOCS1 16p13.13 suppressor of cytokine signaling 1 TNP2 16p13.13 transition protein 2 (during histone to protamine replacement) PRM2 16p13.13 protamine 2 PRM1 16p13.13 protamine 1 MGC24665 16p13.2 hypothetical protein MGC24665 LOC388210 16 similar to CG15828-PA LOC388211 16 hypothetical gene supported by AK126539 LITAF 16p13.3-p12 lipopolysaccharide-induced TNF factor SNN 16p13 stannin LOC51061 16p13.13 hypothetical protein LOC51061 FLJ21777 16p13.13 hypothetical protein FLJ21777 HSPC055 16p13-p12 zinc-finger protein AY163807 LOC388212 16 LOC388212 DKFZP564M182 16p13.13 DKFZP564M182 protein GSPT1 16p13.13 G1 to S phase transition 1 COX6CP1 16p12 cytochrome c oxidase subunit VIc pseudogene 1 LOC348151 16p13.13 similar to nuclear pore complex interacting protein TNFRSF17 16p13.1 tumor necrosis factor receptor superfamily, member 17 FLJ12363 16p13.13 hypothetical protein FLJ12363 LOC92017 16p13.13 similar to RIKEN cDNA 4933437K13 LOC388213 16 LOC388213 FLJ11151 16p13.13 hypothetical protein FLJ11151
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 2642 - 161 - 2003 12655064
    4 - 2479 - 161 - 2003 12655064
    5 - 2577 - 152 - 2003 12655064
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
    Endocrineadrenal gland   highly
    Lymphoid/Immunespleen   predominantly
    Nervousnervespinal nerve  highly Homo sapiens
    Reproductivefemale systemuteruscervix highly
     male systemprostate   
    Skin/Tegumentskin    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    NervousSchawnn cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminus containing two PPXY motifs that mediate protein-protein interactions with WW-domain containing proteins
  • a PPXY motif
  • P(S/T)AP motifs
  • C-terminus containing a highly conserved domain termed the SIMPLE-like domain (SLD)
  • a transmembrane domain (TMD) embedded within the cysteine-rich (C-rich) region that anchors LITAF to the membrane
  • mono polymer aggregate
    HOMOLOGY
    interspecies homolog to murine Litaf
    homolog to xenopus Xl.21754
    Homologene
    FAMILY RING finger motif-containing subfamily of E3 ubiquitin ligases
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    intracellular,nucleus
    basic FUNCTION
  • playing an important role in the regulation of tumor necrosis factor alpha (TNFA)
  • may be clathrin adaptor aiding in the retention of ubiquitinated proteins on to the endosomes
  • E3 ubiquitin ligase playing a role in protein degradation
  • multiple functional molecule whose sequence is identical to the small integral membrane protein of the lysosome/late endosome
  • mediates the effect of AMPK by binding to a specific sequence in the promoter region
  • may function as a tumor suppressor
  • is a post-translationally inserted, C-tail-anchored membrane protein
  • transcription factor that mediates TNF1 expression (
  • CELLULAR PROCESS nucleotide, transcription, regulation
    protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component LITAF forms a complex with human STAT6, which translocates into the nucleus to upregulate cytokine transcription (
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding with TNF
  • ITCH, a WW-domain containing protein, and LITAF strongly interact and this interaction depends on the two PPXY motifs in the N-terminus of LITAF
  • TWIST1-binding sequences associated with CHST11, LITAF, ROR2, and SPATA5 also bound the potential TWIST1 cofactor RREB1
  • cell & other
    REGULATION
    activated by AMPK (AMPK activation upregulates the transcription of LITAF)
    induced by by lipopolysaccharides (lps) or TP53
    ASSOCIATED DISORDERS
    corresponding disease(s) CMT1C
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS