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FLASH GENE
Symbol LRRTM1 contributors: mct - updated : 30-05-2016
HGNC name leucine-rich repeat transmembrane neuronal 1 protein
HGNC id 19408
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal sequence
  • ten extracellular LRR domains flanked by cysteine-rich domains
  • a TM domain
  • HOMOLOGY
    Homologene
    FAMILY
  • LRRTM family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • playing a role in the formation and maintenance of the central nervous system
  • may have played a role in human cognitive and behavioral evolution
  • postsynaptic cell adhesion molecule that bind to presynaptic neurexins
  • LRRTM1, LRRTM2 are essential for maintenance of long-term potentiation
  • synaptic organizers, LRRTM1 and LRRTM2, are targets of nuclear calcium signaling
  • LRRTM1, LRRTM2, LRRTM3, LRRTM4 are postsynaptic adhesion molecules essential for excitatory synapse development
  • LRRTM1, LRRTM2 function as postsynaptic organizers that induce excitatory synapses
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • selective binding between NRXN1 and LRRTM1/LRRTM2 modulated by the S4 insertion of NRXN1
  • cell & other
    REGULATION
    induced by nuclear calcium signaling that induces expression of the synaptic organizer LRRTM1 and LRRTM2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • candidate gene for involvement in several common neurodevelopmental disorders
  • for handedness
  • Marker
    Therapy target
    ANIMAL & CELL MODELS