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FLASH GENE
Symbol LRRTM1 contributors: mct - updated : 30-05-2016
HGNC name leucine-rich repeat transmembrane neuronal 1 protein
HGNC id 19408
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainforebraincerebral cortex  
 braindiencephalonthalamus  
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
IMPRINTING
text regulated by imprinting
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal sequence
  • ten extracellular LRR domains flanked by cysteine-rich domains
  • a TM domain
    • HOMOLOGY
    Homologene
    FAMILY
  • LRRTM family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • playing a role in the formation and maintenance of the central nervous system
  • may have played a role in human cognitive and behavioral evolution
  • postsynaptic cell adhesion molecule that bind to presynaptic neurexins
  • LRRTM1, LRRTM2 are essential for maintenance of long-term potentiation
  • synaptic organizers, LRRTM1 and LRRTM2, are targets of nuclear calcium signaling
  • LRRTM1, LRRTM2, LRRTM3, LRRTM4 are postsynaptic adhesion molecules essential for excitatory synapse development
  • LRRTM1, LRRTM2 function as postsynaptic organizers that induce excitatory synapses
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • selective binding between NRXN1 and LRRTM1/LRRTM2 modulated by the S4 insertion of NRXN1
    • cell & other
    REGULATION
    induced by nuclear calcium signaling that induces expression of the synaptic organizer LRRTM1 and LRRTM2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • candidate gene for involvement in several common neurodevelopmental disorders
  • for handedness
    • Marker
    Therapy target
    ANIMAL & CELL MODELS