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FLASH GENE

Symbol

LRRTM1

contributors: mct - updated : 30-05-2016

HGNC name	leucine-rich repeat transmembrane neuronal 1 protein
HGNC id	19408

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	gene in gene
text	CTNNA genes contain antisense oriented leucine rich repeat transmembrane (LRRTM) genes within their seventh introns (CTNNA2 containing LRRTM1)
STRUCTURE	2.48 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

text structure

residing within an intron of CTNNA2 (between exon 6 and 7 )

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_178839 2 - 2217 58.51 522 - 2003 12676565

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain forebrain cerebral cortex       brain diencephalon thalamus

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

IMPRINTING
text	regulated by imprinting

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a signal sequence
	ten extracellular LRR domains flanked by cysteine-rich domains
	a TM domain

HOMOLOGY

Homologene

FAMILY

LRRTM family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum

basic FUNCTION	playing a role in the formation and maintenance of the central nervous system
	may have played a role in human cognitive and behavioral evolution
	postsynaptic cell adhesion molecule that bind to presynaptic neurexins
	LRRTM1, LRRTM2 are essential for maintenance of long-term potentiation
	synaptic organizers, LRRTM1 and LRRTM2, are targets of nuclear calcium signaling
	LRRTM1, LRRTM2, LRRTM3, LRRTM4 are postsynaptic adhesion molecules essential for excitatory synapse development
	LRRTM1, LRRTM2 function as postsynaptic organizers that induce excitatory synapses

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

selective binding between NRXN1 and LRRTM1/LRRTM2 modulated by the S4 insertion of NRXN1

cell & other

REGULATION

induced by

nuclear calcium signaling that induces expression of the synaptic organizer LRRTM1 and LRRTM2

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene	candidate gene for involvement in several common neurodevelopmental disorders
	for handedness
Marker
Therapy target

ANIMAL & CELL MODELS