Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol LRRTM1 contributors: mct - updated : 30-05-2016
HGNC name leucine-rich repeat transmembrane neuronal 1 protein
HGNC id 19408
Location 2p12      Physical location : 80.529.002 - 80.531.487
Synonym symbol(s) FLJ32082, UNQ675/PRO1309
DNA
TYPE functioning gene
SPECIAL FEATURE gene in gene
text
  • CTNNA genes contain antisense oriented leucine rich repeat transmembrane (LRRTM) genes within their seventh introns (CTNNA2 containing LRRTM1)
    • STRUCTURE 2.48 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure
  • residing within an intron of CTNNA2 (between exon 6 and 7 )
    • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 2217 58.51 522 - 2003 12676565
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainforebraincerebral cortex  
     braindiencephalonthalamus  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    IMPRINTING
    text regulated by imprinting
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal sequence
  • ten extracellular LRR domains flanked by cysteine-rich domains
  • a TM domain
    • HOMOLOGY
    Homologene
    FAMILY
  • LRRTM family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • playing a role in the formation and maintenance of the central nervous system
  • may have played a role in human cognitive and behavioral evolution
  • postsynaptic cell adhesion molecule that bind to presynaptic neurexins
  • LRRTM1, LRRTM2 are essential for maintenance of long-term potentiation
  • synaptic organizers, LRRTM1 and LRRTM2, are targets of nuclear calcium signaling
  • LRRTM1, LRRTM2, LRRTM3, LRRTM4 are postsynaptic adhesion molecules essential for excitatory synapse development
  • LRRTM1, LRRTM2 function as postsynaptic organizers that induce excitatory synapses
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • selective binding between NRXN1 and LRRTM1/LRRTM2 modulated by the S4 insertion of NRXN1
    • cell & other
    REGULATION
    induced by nuclear calcium signaling that induces expression of the synaptic organizer LRRTM1 and LRRTM2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • candidate gene for involvement in several common neurodevelopmental disorders
  • for handedness
    • Marker
    Therapy target
    ANIMAL & CELL MODELS