| basic FUNCTION
| essential for acidification of diverse intracellular compartments  |
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required for urine acidification, and in osteoclasts, playing an important role in bone resorption by acid secretion across the ruffled border membrane |
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regulator of osteoclast fusion and bone formation |
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in the epididymis and vas deferens, the vacuolar H(+)ATPase (V-ATPase), located in the apical pole of narrow and clear cells, is required to establish an acidic luminal pH and also participates in the acidification of intracellular organelles |
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plays an important role in osteoclast maturation and bone formation |
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important subunit of the V-ATPase proton pump, which regulates bone homeostasis |
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having a dual function as a regulator of cell fusion in osteoclast differentiation and as an essential component of the osteoclast-specific proton pump that mediates extracellular acidification in bone resorption |
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required for amino acid signaling to MTOR and functions between amino acids and the nucleotide loading of the Rag GTPases |
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plays a key role in enamel development, specifically lysosomal acidification |
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playing a pivotal role in acid-base homeostasis |
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is a key component of macrophage-specific autophagosome-lysosome fusion machinery maintaining macrophage organelle homeostasis and, in turn, limiting both inflammation and bacterial infection |
