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FLASH GENE

Symbol

RGL4

contributors: npt - updated : 23-01-2006

HGNC name	ral guanine nucleotide dissociation stimulator-like 4
HGNC id	31911

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	22q11.23      Physical location : 24.033.047 - 24.041.358
Synonym name	Ral-GDS related protein Rgr
	RalGDS related oncogene
Synonym symbol(s)	Rgr, HRGR, RRGR, MGC119678, MGC119680

DNA

TYPE	functioning gene
STRUCTURE	8.00 kb     11 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

text	four alternatively spliced full-length transcripts (Leonardi)

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - - 2897 52.3 473 - -

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       lowly Lymphoid/Immune spleen           thymus       highly Nervous brain       lowly Urinary kidney       lowly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow

cell lineage
cell lines
fluid/secretion	blood

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

one Ras-GEF domain

HOMOLOGY

interspecies	ortholog to rabbit rgr
	homolog to chimpanzee LOC458697

Homologene

FAMILY

CATEGORY

protooncogene

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic,vesicle

basic FUNCTION

acting as a guanyl-nucleotide exchange factor

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

text	small GTPase mediated signal transduction

PATHWAY

metabolism

signaling

signal transduction

intracellular signaling cascade

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral somatic mutation       or abnormally truncated transcript are involved in malignancies

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS