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FLASH GENE

Symbol

CTNNA3

contributors: mct - updated : 15-10-2010

HGNC name	catenin (cadherin-associated protein), alpha 3
HGNC id	2511

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   with monoallelic and biallelic expression patterns in tumor bladder tissue constitutional         silencing of STOX1 or CTNNA3 leads to a change in extravillous trophoblast phenotype toward a non-proliferative cell type in the early placenta

Susceptibility

to late-onset Alzheimer disease(LOAD)in females to toluene diisocyanate-induced asthma (TDI)

Variant & Polymorphism SNP	SNP 4360 and 4783 significatively associated with LOAD in females (SNP exhibited no interaction with the APOE-epsilon4 allele)
	polymorphism in the 3' downstream region of CTNNA3 (rs1786929), significantly associated with the TDI-induced asthma phenotype

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS