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FLASH GENE
Symbol CTNNA3 contributors: mct - updated : 15-10-2010
HGNC name catenin (cadherin-associated protein), alpha 3
HGNC id 2511
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Ctnna3
Homologene
FAMILY
  • vinculin/alpha-catenin family
    • CATEGORY adhesion , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    text colocalizes with CTNNA1 at the intercalated discs of cardiomyocytes and in peritubular myoid cells of testis
    basic FUNCTION
  • involved in the organization of the actin cytoskeleton and in cell adhesion
  • necessary for the formation of stretch-resistant cell-cell adhesion complexes, in particular, muscle cells
  • influencing susceptibility to Alzheimer's disease, and the effect is dependent on APOE status
  • provides an indispensable link between a cadherin-based adhesion complex and the actin cytoskeleton, resulting in strong cell-cell adhesion
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with CTNNB1
  • STOX1–CTNNA3 interaction is direct and includes Akt-mediated phosphorylated control of nucleo-cytoplasmic shuttling and ubiquitin-mediated degradation as shared with the FOX multigene family
  • binding of CTNNA3 to plakophilin-2 is proposed to be a means of modulating and strengthening cell-cell adhesion between cardiac muscle cells
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    with monoallelic and biallelic expression patterns in tumor bladder tissue
    constitutional        
    silencing of STOX1 or CTNNA3 leads to a change in extravillous trophoblast phenotype toward a non-proliferative cell type in the early placenta
    Susceptibility
  • to late-onset Alzheimer disease(LOAD)in females
  • to toluene diisocyanate-induced asthma (TDI)
    • Variant & Polymorphism SNP
  • SNP 4360 and 4783 significatively associated with LOAD in females (SNP exhibited no interaction with the APOE-epsilon4 allele)
  • polymorphism in the 3' downstream region of CTNNA3 (rs1786929), significantly associated with the TDI-induced asthma phenotype
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS