Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol EEF1D contributors: mct - updated : 08-04-2014
HGNC name eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
HGNC id 3211
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an eukaryotic elongation factor 1 (EF-1) guanine nucleotide exchange domain
  • a conserved consensus phosphorylation site for the mitotic cyclin-dependent kinase 1 required for its posttranslational modification during mitosis, resulting in lower affinity to its substrate EEF1A
    • HOMOLOGY
    interspecies homolog to rattus Eef1d (87.15 pc)
    homolog to murine Eef1d (85.47 pc)
    intraspecies homolog to EEF1B
    Homologene
    FAMILY
  • EF-1-beta/EF-1-delta family
    • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • having translation factor activity and involved in proline biosynthesis
  • encoding a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome
  • plays a key role in mediating BMP6-induced transcriptional activation of CDH1 in breast cancer cells
  • is likely the switch through which BMP6 restores CDH1-mediated cell-to-cell adhesion and prevents breast cancer metastasis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component 4 subunits: alpha, beta, delta, and gamma
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with HIV-1 Tat
  • TPT1
  • SIAH1-interacting protein and EFF1D functions as a novel negative regulator of SIAH1
  • CSNK2A1 substrate for CSNK2A1 phosphorylation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in cancerous compared to noncancerous oesophageal tissues, and correlated with lymph node metastases, advanced disease stages and poorer prognosis in oesophageal carcinoma
    tumoral     --over  
    in medulloblastoma is adversely associated with with adverse outcome
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS