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FLASH GENE
Symbol CADPS2 contributors: mct - updated : 04-07-2012
HGNC name Ca++-dependent secretion activator 2
HGNC id 16018
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one PH domain
  • N-terminal coiled-coil domain
  • a C2 domain
  • a C-terminal coiled-coil domain
    • HOMOLOGY
    intraspecies homolog to CADPS
    Homologene
    FAMILY CAPS family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • colocalized with BDNF, both synaptically and extrasynaptically in axons of hippocampal neurons
  • somal CADPS2 is associated with the Golgi membrane
    • basic FUNCTION
  • playing a role in regulation of vesicle trafficking and exocytosis
  • CADPS and CADPS2 are essential components of the synaptic vesicle priming machinery
  • essential regulator of synaptic vesicle and large dense core vesicle priming in mammalian neurons and neuroendocrine cells
  • CADPs and CADPS2 promote monoamine uptake and storage mediated by the vesicular monoamine transporters SLC18A1 and SLC18A2
  • enhancing release of BDNF and NTF3, both of which are essential for normal cerebellar development
  • dense-core vesicle-associated protein that is involved in the secretion of BDNF
  • promotes activity-dependent BDNF secretion during the postnatal period that is critical for the development of hippocampal GABAergic networks
  • CADPS2-mediated secretion may contribute to GABA- or BDNF-related network activities and may potentially play a role in psychiatric behavior
  • secretory granule associate protein, mediates monoamine transmission and the release of neurotrophins including brain-derived neurotrophic factor (BDNF)
  • regulates the exocytosis of catecholamine-containing or neuropeptide-containing dense-core vesicles (DCVs) at secretion sites such as nerve terminals
  • exert dual roles in DCV trafficking, mediating trafficking at both the secretion site for exocytosis and at the Golgi complex for biogenesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associated with secretory vesicles containing brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NTF3)
  • mediates binding and recruitment of the GDP-bound form of ARF4 and ARF5 (members of the membrane-trafficking small GTPase family) to the Golgi membrane
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in the brains of schizophrenic patients
    Susceptibility to autistic-like phenotypes
    Variant & Polymorphism other aberrant alternatively spliced CADPS2 mRNA that lacks exon 3 in some autistic patients
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • CAPS2(-/-) and CAPS1(+/-), CAPS2(-/-) mice, despite having increased insulin sensitivity, are glucose intolerant and that this effect is attributable to a marked reduction of glucose-induced insulin secretion