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FLASH GENE
Symbol CADPS2 contributors: mct - updated : 04-07-2012
HGNC name Ca++-dependent secretion activator 2
HGNC id 16018
Location 7q31.1      Physical location : 121.958.478 - 122.526.813
Synonym name Ca2+-dependent activator protein for secretion 2
Synonym symbol(s) CAPS-2, CAPS2, FLJ40851, KIAA1591
DNA
TYPE functioning gene
STRUCTURE 568.34 kb     30 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
KCND2 7q31-q32 potassium voltage-gated channel, Shal-related subfamily, member 2 TM4SF12 7 transmembrane 4 superfamily member 12 ING3 7q31 inhibitor of growth family, member 3 FLJ21986 7q31.32 hypothetical protein FLJ21986 WNT16 7q31 wingless-type MMTV integration site family, member 16 FAM3C 7q22.1-q31.1 family with sequence similarity 3, member C HCP19 7q31.32 cytochrome c, somatic pseudogene LOC136143 7q31.32 similar to ribosomal protein L18; 60S ribosomal protein L18 PTPRZ1 7q31.3 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 AASS 7q31.3 aminoadipate-semialdehyde synthase LOC389549 7 similar to zinc finger protein 312; forebrain embryonic zinc finger CADPS2 7q31.1 Ca2+-dependent activator protein for secretion 2 RNF133 7q31.33 ring finger protein 133 RNF148 7q31.33 ring finger protein 148 TAS2R16 7q31.1-q31.3 taste receptor, type 2, member 16 SLC13A1 7q31-q32 solute carrier family 13 (sodium/sulfate symporters), member 1 FLJ35834 7q31.33 hypothetical protein FLJ35834 NDUFA5 7q31.33 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa ASB15 7q31.31 ankyrin repeat and SOCS box-containing 15 LOC389550 7 similar to cardiac leiomodin WASL 7q31.3 Wiskott-Aldrich syndrome-like HYAL4 7q31.3 hyaluronoglucosaminidase 4 SPAM1 7q31.3 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) LOC340344 7q31.33 similar to RIKEN cDNA 6332401O19 gene LOC136157 7q31.33 similar to RIKEN cDNA 1500011L16 LOC346643 7q31.33 similar to 40S ribosomal protein S2 GPR37 7q31 G protein-coupled receptor 37 (endothelin receptor type B-like) LOC154872 7q31.33 hypothetical LOC154872 POT1 7q31.33 protection of telomeres 1 LOC392094 7 similar to Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma) (PRO1608)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
30 - 6074 147.6 1296 - 2007 17380209
28 - 5951 143.3 1255 - 2007 17380209
30 - 6086 - 1300 - 2007 17380209
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainhindbraincerebellum   Homo sapiens
 brainlimbic systemhippocampus   Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Homo sapiens
not specificgranular cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one PH domain
  • N-terminal coiled-coil domain
  • a C2 domain
  • a C-terminal coiled-coil domain
  • HOMOLOGY
    intraspecies homolog to CADPS
    Homologene
    FAMILY CAPS family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • colocalized with BDNF, both synaptically and extrasynaptically in axons of hippocampal neurons
  • somal CADPS2 is associated with the Golgi membrane
  • basic FUNCTION
  • playing a role in regulation of vesicle trafficking and exocytosis
  • CADPS and CADPS2 are essential components of the synaptic vesicle priming machinery
  • essential regulator of synaptic vesicle and large dense core vesicle priming in mammalian neurons and neuroendocrine cells
  • CADPs and CADPS2 promote monoamine uptake and storage mediated by the vesicular monoamine transporters SLC18A1 and SLC18A2
  • enhancing release of BDNF and NTF3, both of which are essential for normal cerebellar development
  • dense-core vesicle-associated protein that is involved in the secretion of BDNF
  • promotes activity-dependent BDNF secretion during the postnatal period that is critical for the development of hippocampal GABAergic networks
  • CADPS2-mediated secretion may contribute to GABA- or BDNF-related network activities and may potentially play a role in psychiatric behavior
  • secretory granule associate protein, mediates monoamine transmission and the release of neurotrophins including brain-derived neurotrophic factor (BDNF)
  • regulates the exocytosis of catecholamine-containing or neuropeptide-containing dense-core vesicles (DCVs) at secretion sites such as nerve terminals
  • exert dual roles in DCV trafficking, mediating trafficking at both the secretion site for exocytosis and at the Golgi complex for biogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associated with secretory vesicles containing brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NTF3)
  • mediates binding and recruitment of the GDP-bound form of ARF4 and ARF5 (members of the membrane-trafficking small GTPase family) to the Golgi membrane
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in the brains of schizophrenic patients
    Susceptibility to autistic-like phenotypes
    Variant & Polymorphism other aberrant alternatively spliced CADPS2 mRNA that lacks exon 3 in some autistic patients
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • CAPS2(-/-) and CAPS1(+/-), CAPS2(-/-) mice, despite having increased insulin sensitivity, are glucose intolerant and that this effect is attributable to a marked reduction of glucose-induced insulin secretion